Whilst minimal-rely MBL almost never progresses to CLL, substantial-depend MBL progresses to CLL necessitating therapy at a fee of one% to two% per annum. Superior-depend MBL is distinguished from Rai 0 CLL depending on if the B-mobile depend is above or under 5 × 109/L. Even though people with each substantial-count MBL and CLL Rai stage 0 are at